Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention
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چکیده
منابع مشابه
Heterodimeric capping protein from Arabidopsis is regulated by phosphatidic acid.
The cytoskeleton is a key regulator of morphogenesis, sexual reproduction, and cellular responses to extracellular stimuli. Changes in the cellular architecture are often assumed to require actin-binding proteins as stimulus-response modulators, because many of these proteins are regulated directly by binding to intracellular second messengers or signaling phospholipids. Phosphatidic acid (PA) ...
متن کاملLocalization of Phosphatidic Acid Phosphatase Activity in Granular Pneumonocytes
The alveoli of the mammalian lung are lined by a film of surface-active material (surfactant) which is commonly believed to be a phospholipid (1, 5, 8, 11) . A considerable body of evidence has accumulated which suggests that surfactant is synthesized by the granular pneumonocytes (type II cells) of the alveolar epithelium (1, 9, 10) . Although a number of acid hydrolases have been demonstrated...
متن کاملPhosphatidic Acid Synthesis in Yeast.
1. The presence of palmitoyl-CoA-l-glycerol 1-phosphate palmitoyltransferase (EC2.3.1.15) has been demonstrated in a particulate fraction of baker's yeast. 2. The enzyme has been characterized, and its activity studied as a function of pH and concentration of substrates. 3. Inhibition by thiol poisons and protection by acyl-CoA have been used to obtain information on the active site. 4. By vari...
متن کاملPulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
The lung contains two distinct forms of phosphatidic acid phosphatase (PAP). PAP1 is a cytosolic enzyme that is activated through fatty acid-induced translocation to the endoplasmic reticulum, where it converts phosphatidic acid (PA) to diacylglycerol (DAG) for the biosynthesis of phospholipids and neutral lipids. PAP1 is Mg(2+) dependent and sulfhydryl reagent sensitive. PAP2 is a six-transmem...
متن کاملActivation of Phospholipase D by Phosphatidic Acid
The activity of bacterial phospholipase D (PLD), a Ca-dependent enzyme, toward phosphatidylcholine bilayers was enhanced 7-fold by incorporation of 10 mol % phosphatidic acid (PA) in the vesicle bilayer. Addition of other negatively charged lipids such as phosphatidylinositol, phosphatidylmethanol, and oleic acid either inhibited or had no effect on enzyme activity. Only negatively charged lipi...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2019
ISSN: 2058-7716
DOI: 10.1038/s41420-019-0187-1